Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease\n(NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to\nprevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In\nmurine models, time-restricted feeding resets the hepatic circadian clock and enhances transcription of key metabolic regulators\nof glucose and lipid homeostasis. Studies of the effect of dawn-to-sunset Ramadan fasting, which is akin to time-restricted\nfeeding model, have also identified significant improvement in body mass index, serum lipid profiles, and oxidative stress\nparameters. Based on the findings of studies conducted on human subjects, dawn-to-sunset fasting has the potential to be a\ncost-effective intervention for obesity, metabolic syndrome, and NAFLD.
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